The investigation of miR-499 in apoptosis of cardiomyocytes in blood serum of MI patients

Background: Ischemic heart diseases (IHD) cause most deaths worldwide in a way that they are the cause of more than 30 percent of the deaths. After the discovery of miRNA in 1990 and the discovery of more than 2500 types of miRNA, gradually the importance of these mechanism regulators and molecular signals and gene routes were identified in the processes and the cellular mechanisms, especially in cardiovascular system. The goal of this research was to investigate miR-499 dominating the apoptosis of heart cellules in serums of the patients with MI (myocardial infarction). Materials and methods: In this case-control study, miR-499 were investigated by real time PCR among 70 MI patients in Shahid Madani Hospital in Tabriz in 2017 and the data were compared with healthy persons. The statistical analyses were carried out using SPSS (version19) by t-test method. P<0.05 were considered as significant. Results: The expression levels of miR-499 significantly increased among MI patients compared to control group (P=0.007). The miR-499 expression has no significant difference between overweight and normal weight people (P=0.06). Conclusion: The present study showed that the expression of miR-499 among individuals suffering from MI has been greater than healthy people and it can be utilized as a diagnostic and also prognostic factor of MI patients. Keywords: Acute myocardial infarction, Apoptosis, miR-499.